I love the B06 Modern Opening for Black:

[Title "White - Black"]
[FEN ""]

1. e4 d6 2. d4 g6 3. Nc3 Bg7 4. Bc4 e6 5. Nf3 Ne7 6. Bg5 h6 7. Bh4 a6 8.O-O Nd7

I find it leads to a strong position for White to attack and a secure one for Black to defend (especially if it leads you to the Hippo Defense because, as Black, I've had my greatest success with atypical openings:

[Title "Petrosian vs. Spassky, World Championship 1966 (game 16)"]
[FEN ""]

1.d4 g6 2.e4 Bg7 3.Nf3 d6 4.Be2 e6 5.c3 Nd7 6.0-0 Ne7 7.Nbd2 b6 8.a4 a6 9.Re1 Bb7 10.Bd3 0-0

Question: What are the major defences that statistically have seen the most success by Black?