Gambits are often a good way to get your opponent out of their comfort zone.  As white, some good gambits include:

 - the Morra Gambit
 - the Evan's Gambit
 - 4.Ng5 in the Two Knight's Defense (black is sacrificing a pawn here though!)

For black, the Sicilian and the King's Indian are good ways to create a double edged game.  A line that you know by heart in the Sicilian is probably your best bet.  Against d4 you can consider playing an early c5 with the Benko Gambit or the Benoni - both of which can lead to an unbalanced game as well.  White probably has a fairly good idea of what to do against the KID because it is so common which is why either the Benko or the Benoni can be a nice change of pace.