Centipawn loss isn't sufficient to reflect the playing strength of a player, as some positions are more complex to play than others. A centipawn loss of 20 is more challenging to reach in a wild King's Gambit than in some calm d4 opening.
Is there any statistical analysis of the average centipawn loss per opening? It would also be interesting to differentiate between masters/amateurs.
Would that be a good measure of how hard an opening is to play well, or would it be distorted by weighing tactical/calculation mistakes much more severe than positional inaccuracies?