Assuming one or both players makes a mistake and transposes a bishop and the adjacent knight when setting up the board, would this help or hinder them?
The answers to this similar question suggest it's a disadvantage. However using the lichess board editor for different variations of this (one vs both sides with both on light squared or dark squares, etc) generally shows a larger starting advantage for white for all variations in the stockfish evaluation (up to +0.8 for white having 2 dark-squared and black 2 light-squared, and +0.2 for black being normal but white having 2 dark-squared compared to +0.1 for the standard start), but I'm not sure how valid this analysis is for an alternate starting position.