More or less what is asked in the title. I am familiar with how the system itself works, but I am wondering if there would be any issues if most chess tournaments didn't follow the Swiss format and to a lesser extent, round-robin and match formats which all have each player play a similar number of games. However, consider a single-or double-elimination tournament bracket, which would mean that when a system was first implemented, stronger players would be playing more games in those tournaments than the weaker players who would be eliminated sooner.
Also the question is not limited to issues in relation to the accuracy of the ratings in a statistical sense, though that would of course be the main consideration.